{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Q"],"funding":["NIA NIH HHS","National Cancer Institute","NCI NIH HHS","National Institutes of Health","NIAMS NIH HHS"],"pagination":["179-90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5235362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(5-6)"],"pubmed_abstract":["Dystrophic cardiac calcinosis (DCC), also called epicardial and myocardial fibrosis and mineralization, has been detected in mice of a number of laboratory inbred strains, most commonly C3H/HeJ and DBA/2J. In previous mouse breeding studies between these DCC susceptible and the DCC-resistant strain C57BL/6J, 4 genetic loci harboring genes involved in DCC inheritance were identified and subsequently termed Dyscalc loci 1 through 4. Here, we report susceptibility to cardiac fibrosis, a sub-phenotype of DCC, at 12 and 20 months of age and close to natural death in a survey of 28 inbred mouse strains. Eight strains showed cardiac fibrosis with highest frequency and severity in the moribund mice. Using genotype and phenotype information of the 28 investigated strains, we performed genome-wide a"],"journal":["Mammalian genome : official journal of the International Mammalian Genome Society"],"pubmed_title":["Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis."],"pmcid":["PMC5235362"],"funding_grant_id":["K01 AR064766","K01AR064766","P30 CA056036","P30 CA034196","P30 AG025707","CA34196","R01AR055225","R01 AR055225"],"pubmed_authors":["Schofield PN","Cario CL","Richardson MA","Uitto J","Silva KA","Sundberg JP","Berndt A","Chase TH","Li Q","Sundberg BA","Kennedy VE"],"additional_accession":[]},"is_claimable":false,"name":"Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.","description":"Dystrophic cardiac calcinosis (DCC), also called epicardial and myocardial fibrosis and mineralization, has been detected in mice of a number of laboratory inbred strains, most commonly C3H/HeJ and DBA/2J. In previous mouse breeding studies between these DCC susceptible and the DCC-resistant strain C57BL/6J, 4 genetic loci harboring genes involved in DCC inheritance were identified and subsequently termed Dyscalc loci 1 through 4. Here, we report susceptibility to cardiac fibrosis, a sub-phenotype of DCC, at 12 and 20 months of age and close to natural death in a survey of 28 inbred mouse strains. Eight strains showed cardiac fibrosis with highest frequency and severity in the moribund mice. Using genotype and phenotype information of the 28 investigated strains, we performed genome-wide a","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jun","modification":"2025-04-05T14:11:25.966Z","creation":"2019-03-27T02:34:08Z"},"accession":"S-EPMC5235362","cross_references":{"pubmed":["27126641"],"doi":["10.1007/s00335-016-9634-y"]}}