{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeffers SA"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","ODCDC CDC HHS","NCI NIH HHS"],"pagination":["15748-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC524836"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["101(44)"],"pubmed_abstract":["Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S glycoprotein were inoculated with SARS-CoV, and increases in subgenomic viral RNA from 1-16"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus."],"pmcid":["PMC524836"],"funding_grant_id":["R01 HL 67671","N01AI65315","901 CCU 216988","N01 AI 25490","R01 AI025231","N01 AI 25489","R01 AI 25231","T32 AI007537","N01 AI 65315","P30 CA046934","P01 AI 59576","P01 AI059576","N01AI25489","P30 CA 046934","T32 AI 07537-04","P01 HL067671","N01AI25490"],"pubmed_authors":["Tusell SM","Jeffers SA","Wentworth DE","Gillim-Ross L","Achenbach JE","Thomas WD","Babcock GJ","Demartini JC","Ambrosino DM","Holmes KV","Thackray LB","Mason RJ","Hemmila EM","Young MD"],"additional_accession":[]},"is_claimable":false,"name":"CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.","description":"Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S glycoprotein were inoculated with SARS-CoV, and increases in subgenomic viral RNA from 1-16","dates":{"release":"2004-01-01T00:00:00Z","publication":"2004 Nov","modification":"2025-04-27T00:42:51.814Z","creation":"2019-03-27T01:08:18Z"},"accession":"S-EPMC524836","cross_references":{"pubmed":["15496474"],"doi":["10.1073/pnas.0403812101"]}}