biostudies-literatureJeffers SANIAID NIH HHSNHLBI NIH HHSODCDC CDC HHSNCI NIH HHS15748-53https://www.ebi.ac.uk/biostudies/studies/S-EPMC524836biostudies-literatureUnknown101(44)Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S glycoprotein were inoculated with SARS-CoV, and increases in subgenomic viral RNA from 1-16Proceedings of the National Academy of Sciences of the United States of AmericaCD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.PMC524836R01 HL 67671N01AI65315901 CCU 216988N01 AI 25490R01 AI025231N01 AI 25489R01 AI 25231T32 AI007537N01 AI 65315P30 CA046934P01 AI 59576P01 AI059576N01AI25489P30 CA 046934T32 AI 07537-04P01 HL067671N01AI25490Tusell SMJeffers SAWentworth DEGillim-Ross LAchenbach JEThomas WDBabcock GJDemartini JCAmbrosino DMHolmes KVThackray LBMason RJHemmila EMYoung MDfalseCD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S glycoprotein were inoculated with SARS-CoV, and increases in subgenomic viral RNA from 1-162004-01-01T00:00:00Z2004 Nov2025-04-27T00:42:51.814Z2019-03-27T01:08:18ZS-EPMC5248361549647410.1073/pnas.0403812101