{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lecendreux M"],"funding":["Agence Nationale de la Recherche"],"pagination":["e0169836"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5249232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (<110 pg/ml). This specific loss of hypocretin and the strong association with the HLA-DQB1*06:02 allele led to the hypothesis that NT1 could be an immune-mediated pathology. Moreover, susceptibility to NT1 has recently been associated with several pathogens, particularly with influenza A H1N1 virus either through infection or vaccination. The goal of this study was to compare peripheral blood immune cell populations in recent onset pediatric NT1 subjects (post or non-post 2009-influ"],"journal":["PloS one"],"pubmed_title":["Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells."],"pmcid":["PMC5249232"],"funding_grant_id":["PHRC AOM07-138, Narcobank","ANR-11-IDEX-0004-02"],"pubmed_authors":["Regnault A","Pitoiset F","Churlaud G","Lecendreux M","Klatzmann D","Tran TA","Liblau R","Rosenzwajg M"],"additional_accession":[]},"is_claimable":false,"name":"Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells.","description":"Narcolepsy is a rare neurologic disorder characterized by excessive daytime sleepiness, cataplexy and disturbed nocturnal sleep patterns. Narcolepsy type 1 (NT1) has been shown to result from a selective loss of hypothalamic hypocretin-secreting neurons with patients typically showing low CSF-hypocretin levels (<110 pg/ml). This specific loss of hypocretin and the strong association with the HLA-DQB1*06:02 allele led to the hypothesis that NT1 could be an immune-mediated pathology. Moreover, susceptibility to NT1 has recently been associated with several pathogens, particularly with influenza A H1N1 virus either through infection or vaccination. The goal of this study was to compare peripheral blood immune cell populations in recent onset pediatric NT1 subjects (post or non-post 2009-influ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-18T23:57:35.258Z","creation":"2019-03-26T22:51:35Z"},"accession":"S-EPMC5249232","cross_references":{"pubmed":["28107375"],"doi":["10.1371/journal.pone.0169836"]}}