{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yousif N"],"funding":["Biotechnology and Biological Sciences Research Council","Bupa Foundation","Engineering and Physical Sciences Research Council","National Tremor Foundation"],"pagination":["e1005326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5261813"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Essential tremor (ET), a movement disorder characterised by an uncontrollable shaking of the affected body part, is often professed to be the most common movement disorder, affecting up to one percent of adults over 40 years of age. The precise cause of ET is unknown, however pathological oscillations of a network of a number of brain regions are implicated in leading to the disorder. Deep brain stimulation (DBS) is a clinical therapy used to alleviate the symptoms of a number of movement disorders. DBS involves the surgical implantation of electrodes into specific nuclei in the brain. For ET the targeted region is the ventralis intermedius (Vim) nucleus of the thalamus. Though DBS is effective for treating ET, the mechanism through which the therapeutic effect is obtained is not understoo"],"journal":["PLoS computational biology"],"pubmed_title":["A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation."],"pmcid":["PMC5261813"],"funding_grant_id":["BB/G006369/1","EP/D036364/1","BB/L000814/1"],"pubmed_authors":["Yousif N","Mace M","Pavese N","Bain P","Nandi D","Borisyuk R"],"additional_accession":[]},"is_claimable":false,"name":"A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation.","description":"Essential tremor (ET), a movement disorder characterised by an uncontrollable shaking of the affected body part, is often professed to be the most common movement disorder, affecting up to one percent of adults over 40 years of age. The precise cause of ET is unknown, however pathological oscillations of a network of a number of brain regions are implicated in leading to the disorder. Deep brain stimulation (DBS) is a clinical therapy used to alleviate the symptoms of a number of movement disorders. DBS involves the surgical implantation of electrodes into specific nuclei in the brain. For ET the targeted region is the ventralis intermedius (Vim) nucleus of the thalamus. Though DBS is effective for treating ET, the mechanism through which the therapeutic effect is obtained is not understoo","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-05-29T19:57:34.749Z","creation":"2025-05-29T19:57:34.749Z"},"accession":"S-EPMC5261813","cross_references":{"pubmed":["28068428"],"doi":["10.1371/journal.pcbi.1005326"]}}