{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nelson KN"],"funding":["NCATS NIH HHS","NIAID NIH HHS"],"pagination":["571-575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5263111"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(4)"],"pubmed_abstract":["OBJECTIVE:HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNA methylation (DNAm) age, an aging marker involving multiple age-related cytosine-guanine dinucleotide (CpG) sites, among antiretroviral treatment (ART)-naive HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study. DESIGN:Peripheral blood samples were collected from 19 ART-naive, HIV-positive, and 19 HIV-negative male participants, matched by age and race. Blood samples were collected from HIV-positive participants 7-11 years after ART initiation. METHODS:We compared DNAm age between HIV-positive and HIV-negative groups at baseline and between HIV-positive patients at baseline and follow-up. We also performed an epigenome-wide analysis to identify CpG methylation sites associated with HIV infection. RESULTS:DNAm age in HIV-positive individuals is, on average, 11.2 years higher than HIV study participants at baseline, and two of 10 HIV-positive individuals showed an increase in DNAm age after ART initiation. Epigenome-wide association studies showed an association of HIV infection with one site, in gene VPS37B, which approached statistical significance in our cohort (P?=?3.30?×?10, Bonferroni-corrected threshold?=?1.22?×?10) and was replicated in a second, larger cohort. CONCLUSION:ART treatment-naive HIV-positive individuals have significantly older DNAm age compared to HIV-negative individuals in the Veterans Aging Cohort Study cohort. Longitudinal changes in DNAm age are highly variable across individuals after initiation of antiretroviral therapy."],"journal":["AIDS (London, England)"],"pubmed_title":["Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans."],"pmcid":["PMC5263111"],"funding_grant_id":["UL1 TR001863","P30 AI050409"],"pubmed_authors":["Hui Q","Xu K","Freiberg MS","Marconi VC","Sun YV","Rimland D","Justice AC","Nelson KN"],"additional_accession":[]},"is_claimable":false,"name":"Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans.","description":"OBJECTIVE:HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNA methylation (DNAm) age, an aging marker involving multiple age-related cytosine-guanine dinucleotide (CpG) sites, among antiretroviral treatment (ART)-naive HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study. DESIGN:Peripheral blood samples were collected from 19 ART-naive, HIV-positive, and 19 HIV-negative male participants, matched by age and race. Blood samples were collected from HIV-positive participants 7-11 years after ART initiation. METHODS:We compared DNAm age between HIV-positive and HIV-negative groups at baseline and between HIV-positive patients at baseline and follow-up. We also performed an epigenome-wide analysis to identify CpG methylation sites associated with HIV infection. RESULTS:DNAm age in HIV-positive individuals is, on average, 11.2 years higher than HIV study participants at baseline, and two of 10 HIV-positive individuals showed an increase in DNAm age after ART initiation. Epigenome-wide association studies showed an association of HIV infection with one site, in gene VPS37B, which approached statistical significance in our cohort (P?=?3.30?×?10, Bonferroni-corrected threshold?=?1.22?×?10) and was replicated in a second, larger cohort. CONCLUSION:ART treatment-naive HIV-positive individuals have significantly older DNAm age compared to HIV-negative individuals in the Veterans Aging Cohort Study cohort. Longitudinal changes in DNAm age are highly variable across individuals after initiation of antiretroviral therapy.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2020-10-29T13:55:46Z","creation":"2019-03-26T23:03:03Z"},"accession":"S-EPMC5263111","cross_references":{"pubmed":["27922854"],"doi":["10.1097/QAD.0000000000001360","10.1097/qad.0000000000001360"]}}