{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Liu H"],"pubmed_abstract":["Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2, not Notch1, plays a key role in pancreatic carcinogenesis. As both are transcription factors, examination of their genomic binding sites might reveal interesting functional differences between them. Notch proteins do not have DNA-binding domain. In the canonical Notch signaling pathway, ligand binding induces the release and nuclear translocation of Notch receptor intracellular domains (NICDs), which then interact with the transcription factor CSL, resulting in subsequent activation of the canonical Notch target genes. We investigated the binding si"],"journal":["Journal of Cancer"],"pagination":["65-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5264041"],"repository":["biostudies-literature"],"pubmed_title":["Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells."],"pmcid":["PMC5264041"],"pubmed_authors":["Liu H","Zhou P","Chen J","Zhang YX","Lan H"],"additional_accession":[]},"is_claimable":false,"name":"Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells.","description":"Notch signaling plays a key role in the development of pancreatic cancer. Among the four identified Notch receptors, Notch1 and Notch2 share the highest homology. Notch1 has been reported to be an oncogene but some reports indicate that Notch2, not Notch1, plays a key role in pancreatic carcinogenesis. As both are transcription factors, examination of their genomic binding sites might reveal interesting functional differences between them. Notch proteins do not have DNA-binding domain. In the canonical Notch signaling pathway, ligand binding induces the release and nuclear translocation of Notch receptor intracellular domains (NICDs), which then interact with the transcription factor CSL, resulting in subsequent activation of the canonical Notch target genes. We investigated the binding si","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-01T13:41:01.478Z","creation":"2019-03-27T02:34:52Z"},"accession":"S-EPMC5264041","cross_references":{"pubmed":["28123599"],"doi":["10.7150/jca.16739"]}}