{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ceron CS"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil","Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil"],"pagination":["111-116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5266491"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["We describe the effects of losartan, a selective AT<sub>1</sub> receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled \"Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress\" (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) [1]. Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aorta"],"journal":["Data in brief"],"pubmed_title":["Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats."],"pmcid":["PMC5266491"],"funding_grant_id":["470556/2010-2","2010/05815-4"],"pubmed_authors":["do Vale GT","Simplicio JA","Ceron CS","Passaglia P","Ricci ST","Tirapelli CR"],"additional_accession":[]},"is_claimable":false,"name":"Data on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats.","description":"We describe the effects of losartan, a selective AT<sub>1</sub> receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled \"Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress\" (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) [1]. Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aorta","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2025-04-05T15:33:10.913Z","creation":"2019-03-27T02:34:59Z"},"accession":"S-EPMC5266491","cross_references":{"pubmed":["28149929"],"doi":["10.1016/j.dib.2017.01.006"]}}