biostudies-literatureCeron CSConselho Nacional de Desenvolvimento Científico e Tecnológico, BrazilFundação de Amparo à Pesquisa do Estado de São Paulo, Brazil111-116https://www.ebi.ac.uk/biostudies/studies/S-EPMC5266491biostudies-literatureUnknown11We describe the effects of losartan, a selective AT₁ receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled "Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress" (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) [1]. Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aortaData in briefData on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats.PMC5266491470556/2010-22010/05815-4do Vale GTSimplicio JACeron CSPassaglia PRicci STTirapelli CRfalseData on the effects of losartan on protein expression, vascular reactivity and antioxidant capacity in the aorta of ethanol-treated rats.We describe the effects of losartan, a selective AT₁ receptor antagonist on the alterations induced by treatment with ethanol in the rat aorta. The data shown here are related to the article entitled "Angiotensin type 1 receptor mediates chronic ethanol consumption-induced hypertension and vascular oxidative stress" (P. Passaglia, C.S. Ceron, A.S. Mecawi, J. Antunes-Rodrigues, E.B. Coelho, C.R. Tirapelli, 2015) [1]. Here we include new data on the protective effect of losartan against ethanol-induced oxidative stress. Male Wistar rats treated for 2 weeks with ethanol (20%, vol./vol.) exhibited increased aortic production of reactive oxygen species (ROS) and losartan (10 mg/kg/day; p.o. gavage) prevented this response. Ethanol did not alter the expression of eNOS in the rat aorta2017-01-01T00:00:00Z2017 Apr2025-04-05T15:33:10.913Z2019-03-27T02:34:59ZS-EPMC52664912814992910.1016/j.dib.2017.01.006