{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Martin R"],"funding":["Kreftforeningen","European Union Seventh Framework Programme","NFR","Biotechnology and Biological Sciences Research Council"],"pagination":["175-188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5266790"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(2)"],"pubmed_abstract":["Extracellular cues regulate cell fate, and this is mainly achieved through the engagement of specific transcriptional programs. The TORC1 and TORC2 complexes mediate the integration of nutritional cues to cellular behavior, but their interplay is poorly understood. Here, we use fission yeast to investigate how phosphatase activity participates in this interplay during the switch from proliferation to sexual differentiation. We find that loss of PP2A-B55<sup>Pab1</sup> enhances the expression of differentiation-specific genes and leads to premature conjugation. pab1 deletion brings about a transcriptional profile similar to TORC1 inactivation, and deletion of pab1 overcomes the repression of differentiation genes in cells overexpressing TORC1. Importantly, we show that this effect is mediat"],"journal":["Current biology : CB"],"pubmed_title":["A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast."],"pmcid":["PMC5266790"],"funding_grant_id":["BB/N007697/1","BB/M021483/1","5843744","609020","214049"],"pubmed_authors":["Portantier M","Nyquist-Andersen M","Lopez-Aviles S","Mata J","Martin R","Chica N"],"additional_accession":[]},"is_claimable":false,"name":"A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.","description":"Extracellular cues regulate cell fate, and this is mainly achieved through the engagement of specific transcriptional programs. The TORC1 and TORC2 complexes mediate the integration of nutritional cues to cellular behavior, but their interplay is poorly understood. Here, we use fission yeast to investigate how phosphatase activity participates in this interplay during the switch from proliferation to sexual differentiation. We find that loss of PP2A-B55<sup>Pab1</sup> enhances the expression of differentiation-specific genes and leads to premature conjugation. pab1 deletion brings about a transcriptional profile similar to TORC1 inactivation, and deletion of pab1 overcomes the repression of differentiation genes in cells overexpressing TORC1. Importantly, we show that this effect is mediat","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2026-05-05T16:14:43.384Z","creation":"2026-04-07T21:50:53.306Z"},"accession":"S-EPMC5266790","cross_references":{"pubmed":["28041796"],"doi":["10.1016/j.cub.2016.11.037"]}}