biostudies-literatureUnknown6(1)Muller AContrast enhancement of glioblastomas (GBM) is caused by the decrease in relaxation time, T1. Here, we demonstrate that the quantitative measurement of T1 (qT1) discovers a subtle enhancement in GBM patients that is invisible in standard MRI. We assessed the volume change of this "cloudy" enhancement during radio-chemotherapy and its impact on patients' progression-free survival (PFS). We enrolled 18 GBM patients in this observational, prospective cohort study and measured 3T-MRI pre- and post contrast agent with standard T1-weighted (T1w) and with sequences to quantify T1 before radiation, and at 6-week intervals during radio-chemotherapy. We measured contrast enhancement by subtracting pre from post contrast contrast images, yielding relative signal increase ∆T1w and relative T1 shorteniCancer medicine89-99https://www.ebi.ac.uk/biostudies/studies/S-EPMC5269700biostudies-literatureQuantitative T1-mapping detects cloudy-enhancing tumor compartments predicting outcome of patients with glioblastoma.PMC5269700Ditter PJurcoane AGlas MMuller AMadler BKebir SHattingen EHerrlinger UTzaridis TSchrader FSchild HHfalseQuantitative T1-mapping detects cloudy-enhancing tumor compartments predicting outcome of patients with glioblastoma.Contrast enhancement of glioblastomas (GBM) is caused by the decrease in relaxation time, T1. Here, we demonstrate that the quantitative measurement of T1 (qT1) discovers a subtle enhancement in GBM patients that is invisible in standard MRI. We assessed the volume change of this "cloudy" enhancement during radio-chemotherapy and its impact on patients' progression-free survival (PFS). We enrolled 18 GBM patients in this observational, prospective cohort study and measured 3T-MRI pre- and post contrast agent with standard T1-weighted (T1w) and with sequences to quantify T1 before radiation, and at 6-week intervals during radio-chemotherapy. We measured contrast enhancement by subtracting pre from post contrast contrast images, yielding relative signal increase ∆T1w and relative T1 shorteni2017-01-01T00:00:00Z2017 Jan2025-04-26T12:15:18.124Z2019-03-27T02:35:04ZS-EPMC52697002789181510.1002/cam4.966