{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez Fernandez I"],"funding":["NICHD NIH HHS","NINDS NIH HHS"],"pagination":["386-394"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5272971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(4)"],"pubmed_abstract":["<h4>Objective</h4>To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).<h4>Methods</h4>This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month-21 years of age) with rSE.<h4>Results</h4>We enrolled 189 participants (53% male) with a median (25th-75th percentile) age of 4.2 (1.3-9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5-60] vs 16.5 [5-42.75] minutes, p = 0.858). Patients with a diagnosis of epi"],"journal":["Neurology"],"pubmed_title":["Refractory status epilepticus in children with and without prior epilepsy or status epilepticus."],"pmcid":["PMC5272971"],"funding_grant_id":["K23 NS075363","R01 NS065840","R01 HD073115","U10 NS077311","U01 NS045911"],"pubmed_authors":["McDonough TL","Wilfong A","Carpenter JL","Gaillard WD","Williams K","Gainza-Lein M","Mikati MA","Goldstein JL","Abend NS","Chapman KE","Riviello J","Peariso K","Kapur K","Goodkin HP","Wainwright MS","Jackson MC","Arya R","Sanchez Fernandez I","Brenton JN","Topjian AA","Glauser TA","Helseth A","Tasker RC","Loddenkemper T","pediatric Status Epilepticus Research Group (pSERG)"],"additional_accession":[]},"is_claimable":false,"name":"Refractory status epilepticus in children with and without prior epilepsy or status epilepticus.","description":"<h4>Objective</h4>To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).<h4>Methods</h4>This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month-21 years of age) with rSE.<h4>Results</h4>We enrolled 189 participants (53% male) with a median (25th-75th percentile) age of 4.2 (1.3-9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5-60] vs 16.5 [5-42.75] minutes, p = 0.858). Patients with a diagnosis of epi","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jan","modification":"2025-04-26T12:13:57.812Z","creation":"2019-03-26T22:58:03Z"},"accession":"S-EPMC5272971","cross_references":{"pubmed":["28011930"],"doi":["10.1212/WNL.0000000000003550","10.1212/wnl.0000000000003550"]}}