biostudies-literatureSanchez Fernandez INICHD NIH HHSNINDS NIH HHS386-394https://www.ebi.ac.uk/biostudies/studies/S-EPMC5272971biostudies-literatureUnknown88(4)<h4>Objective</h4>To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).<h4>Methods</h4>This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month-21 years of age) with rSE.<h4>Results</h4>We enrolled 189 participants (53% male) with a median (25th-75th percentile) age of 4.2 (1.3-9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5-60] vs 16.5 [5-42.75] minutes, p = 0.858). Patients with a diagnosis of epiNeurologyRefractory status epilepticus in children with and without prior epilepsy or status epilepticus.PMC5272971K23 NS075363R01 NS065840R01 HD073115U10 NS077311U01 NS045911McDonough TLWilfong ACarpenter JLGaillard WDWilliams KGainza-Lein MMikati MAGoldstein JLAbend NSChapman KERiviello JPeariso KKapur KGoodkin HPWainwright MSJackson MCArya RSanchez Fernandez IBrenton JNTopjian AAGlauser TAHelseth ATasker RCLoddenkemper Tpediatric Status Epilepticus Research Group (pSERG)falseRefractory status epilepticus in children with and without prior epilepsy or status epilepticus.<h4>Objective</h4>To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE).<h4>Methods</h4>This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatric patients (1 month-21 years of age) with rSE.<h4>Results</h4>We enrolled 189 participants (53% male) with a median (25th-75th percentile) age of 4.2 (1.3-9.6) years. Eighty-nine (47%) patients had a prior diagnosis of epilepsy. Thirty-four (18%) patients had a history of SE. The time to the first benzodiazepine was similar in participants with and without a diagnosis of epilepsy (15 [5-60] vs 16.5 [5-42.75] minutes, p = 0.858). Patients with a diagnosis of epi2017-01-01T00:00:00Z2017 Jan2025-04-26T12:13:57.812Z2019-03-26T22:58:03ZS-EPMC52729712801193010.1212/WNL.000000000000355010.1212/wnl.0000000000003550