biostudies-literatureLuciano MMedical Research CouncilBiotechnology and Biological Sciences Research Council449-455https://www.ebi.ac.uk/biostudies/studies/S-EPMC5278943biostudies-literatureUnknown88(5)<h4>Objective</h4>To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years).<h4>Methods</h4>We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.<h4>Results</h4>In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated witNeurologyMediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort.PMC5278943G1001245G0701120MR/N003403/1MR/K026992/1MR/M013111/1Valdes Hernandez MCDeary IJCox SRCraig LCMcNeill GMCorley JLuciano MDickie DAKarama SBastin MEWardlaw JMfalseMediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort.<h4>Objective</h4>To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years).<h4>Methods</h4>We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.<h4>Results</h4>In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated wit2017-01-01T00:00:00Z2017 Jan2025-04-04T08:44:47.626Z2019-03-27T02:35:14ZS-EPMC52789432805300810.1212/WNL.0000000000003559