{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(2)"],"submitter":["Ju-Rong Y"],"pubmed_abstract":["Trichorhinophalangeal 1 (Trps1) is a transcription factor essential for epithelial cell morphogenesis during kidney development, but the role of Trps1 in AKI induced by ischemia-reperfusion (I/R) remains unclear. Our study investigated Trps1 expression during kidney repair after acute I/R in rats and explored the molecular mechanisms by which Trps1 promotes renal tubular epithelial cell proliferation. Trps1 expression positively associated with the extent of renal repair after I/R injury. Compared with wild-type rats, rats with knockdown of Trps1 exhibited significantly delayed renal repair in the moderate I/R model, with lower GFR levels and more severe morphologic injury, whereas rats overexpressing Trps1 exhibited significantly accelerated renal repair after severe I/R injury. Additiona"],"journal":["Journal of the American Society of Nephrology : JASN"],"pagination":["532-544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5280010"],"repository":["biostudies-literature"],"pubmed_title":["Transcription Factor Trps1 Promotes Tubular Cell Proliferation after Ischemia-Reperfusion Injury through cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D and AKT."],"pmcid":["PMC5280010"],"pubmed_authors":["Li-Rong L","Kai-Long L","Ju-Rong Y","Ya-Ni H","Bi-Qiong F","Kun H","Ke-Hong C","Jian-Guo Z"],"additional_accession":[]},"is_claimable":false,"name":"Transcription Factor Trps1 Promotes Tubular Cell Proliferation after Ischemia-Reperfusion Injury through cAMP-Specific 3',5'-Cyclic Phosphodiesterase 4D and AKT.","description":"Trichorhinophalangeal 1 (Trps1) is a transcription factor essential for epithelial cell morphogenesis during kidney development, but the role of Trps1 in AKI induced by ischemia-reperfusion (I/R) remains unclear. Our study investigated Trps1 expression during kidney repair after acute I/R in rats and explored the molecular mechanisms by which Trps1 promotes renal tubular epithelial cell proliferation. Trps1 expression positively associated with the extent of renal repair after I/R injury. Compared with wild-type rats, rats with knockdown of Trps1 exhibited significantly delayed renal repair in the moderate I/R model, with lower GFR levels and more severe morphologic injury, whereas rats overexpressing Trps1 exhibited significantly accelerated renal repair after severe I/R injury. Additiona","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-05-29T22:27:22.249Z","creation":"2019-03-26T22:59:15Z"},"accession":"S-EPMC5280010","cross_references":{"pubmed":["27466160"],"doi":["10.1681/asn.2016010009","10.1681/ASN.2016010009"]}}