{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kimura Y"],"funding":["Aichi Medical University Alumni Association","Agence Nationale de la Recherche","the European Community of the 7th Framework Program"],"pagination":["117-126"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5283514"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Phospholipase A<sub>2</sub> receptor (PLA<sub>2</sub>R) is recognized as a target antigen in primary membranous nephropathy (MN); Anti-α-enolase antibody in primary and secondary MN has been proposed, however, little is known about the potential contribution of α-enolase to the pathogenesis of MN.<h4>Methods</h4>We evaluated circulating antibodies to α-enolase by a dot blotting system and PLA<sub>2</sub>R by indirect immunofluorescence, and glomerular deposition of these proteins in 25 patients with primary MN, 20 patients with secondary MN, 44 patients with collagen disease or severe infection, 60 patients with nephritis (each ten patients of IgA nephropathy, focal segmental gloemrulosclerosis, minimal change nephrotic syndrome, membranoproliferative glomeurlonephritis,"],"journal":["Clinical and experimental nephrology"],"pubmed_title":["Circulating antibodies to α-enolase and phospholipase A<sub>2</sub> receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy."],"pmcid":["PMC5283514"],"funding_grant_id":["ANR-07-Physio-016-01","HEALTH-F2-2007-201590"],"pubmed_authors":["Banno S","Kimura Y","Miura N","Ronco P","Debiec H","Morita H","Yamada H","Imai H"],"additional_accession":[]},"is_claimable":false,"name":"Circulating antibodies to α-enolase and phospholipase A<sub>2</sub> receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy.","description":"<h4>Background</h4>Phospholipase A<sub>2</sub> receptor (PLA<sub>2</sub>R) is recognized as a target antigen in primary membranous nephropathy (MN); Anti-α-enolase antibody in primary and secondary MN has been proposed, however, little is known about the potential contribution of α-enolase to the pathogenesis of MN.<h4>Methods</h4>We evaluated circulating antibodies to α-enolase by a dot blotting system and PLA<sub>2</sub>R by indirect immunofluorescence, and glomerular deposition of these proteins in 25 patients with primary MN, 20 patients with secondary MN, 44 patients with collagen disease or severe infection, 60 patients with nephritis (each ten patients of IgA nephropathy, focal segmental gloemrulosclerosis, minimal change nephrotic syndrome, membranoproliferative glomeurlonephritis,","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-04-08T02:39:17.406Z","creation":"2019-03-27T02:35:20Z"},"accession":"S-EPMC5283514","cross_references":{"pubmed":["26830547"],"doi":["10.1007/s10157-016-1235-2"]}}