{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cole AE"],"funding":["NIGMS NIH HHS"],"pagination":["577-588"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5289838"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["205(2)"],"pubmed_abstract":["While most missense suppressors have very narrow specificities and only suppress the allele against which they were isolated, the sumA missense suppressor from Salmonella enterica serovar Typhimurium is a promiscuous or broad-acting missense suppressor that suppresses numerous missense mutants. The sumA missense suppressor was identified as a glyV tRNA Gly3(GAU/C) missense suppressor that can recognize GAU or GAC aspartic acid codons and insert a glycine amino acid instead of aspartic acid. In addition to rescuing missense mutants caused by glycine to aspartic acid changes as expected, sumA could also rescue a number of other missense mutants as well by changing a neighboring (contacting) aspartic acid to glycine, which compensated for the other amino acid change. Thus the ability of sumA "],"journal":["Genetics"],"pubmed_title":["The Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action."],"pmcid":["PMC5289838"],"funding_grant_id":["R01 GM027068"],"pubmed_authors":["Cole AE","Hani FM","Meservy M","Altman E","Roth JR","Altman R"],"additional_accession":[]},"is_claimable":false,"name":"The Promiscuous sumA Missense Suppressor from Salmonella enterica Has an Intriguing Mechanism of Action.","description":"While most missense suppressors have very narrow specificities and only suppress the allele against which they were isolated, the sumA missense suppressor from Salmonella enterica serovar Typhimurium is a promiscuous or broad-acting missense suppressor that suppresses numerous missense mutants. The sumA missense suppressor was identified as a glyV tRNA Gly3(GAU/C) missense suppressor that can recognize GAU or GAC aspartic acid codons and insert a glycine amino acid instead of aspartic acid. In addition to rescuing missense mutants caused by glycine to aspartic acid changes as expected, sumA could also rescue a number of other missense mutants as well by changing a neighboring (contacting) aspartic acid to glycine, which compensated for the other amino acid change. Thus the ability of sumA ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-19T23:24:07.078Z","creation":"2019-03-26T22:59:36Z"},"accession":"S-EPMC5289838","cross_references":{"pubmed":["27974497"],"doi":["10.1534/genetics.116.196550"]}}