{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeffries CD"],"funding":["NIDDK NIH HHS","NIMH NIH HHS"],"pagination":["e981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5290334"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(12)"],"pubmed_abstract":["Dysregulation of immune system functions has been implicated in schizophrenia, suggesting that immune cells may be involved in the development of the disorder. With the goal of a biomarker assay for psychosis risk, we performed small RNA sequencing on RNA isolated from circulating immune cells. We compared baseline microRNA (miRNA) expression for persons who were unaffected (n=27) or who, over a subsequent 2-year period, were at clinical high risk but did not progress to psychosis (n=37), or were at high risk and did progress to psychosis (n=30). A greedy algorithm process led to selection of five miRNAs that when summed with +1 weights distinguished progressed from nonprogressed subjects with an area under the receiver operating characteristic curve of 0.86. Of the five, miR-941 is human-"],"journal":["Translational psychiatry"],"pubmed_title":["Insights into psychosis risk from leukocyte microRNA expression."],"pmcid":["PMC5290334"],"funding_grant_id":["U01 MH082022","U01 MH082004","U01 MH076989","U01 MH081928","P50 MH066286","P30 DK034987","R01 MH085521","R01 MH076989","U01 MH081984","U01 MH081902","U01 MH081857","U01 MH081988","U01 MH081944"],"pubmed_authors":["Mathalon DH","Addington J","Bearden CE","Cadenhead KS","Cornblatt BA","Walker EF","Woods SW","Perkins DO","Jeffries CD","Glatt SJ","Stark T","McGlashan TH","Tsuang M","Seidman LJ","Chandler SD","Yeo E","Cannon TD"],"additional_accession":[]},"is_claimable":false,"name":"Insights into psychosis risk from leukocyte microRNA expression.","description":"Dysregulation of immune system functions has been implicated in schizophrenia, suggesting that immune cells may be involved in the development of the disorder. With the goal of a biomarker assay for psychosis risk, we performed small RNA sequencing on RNA isolated from circulating immune cells. We compared baseline microRNA (miRNA) expression for persons who were unaffected (n=27) or who, over a subsequent 2-year period, were at clinical high risk but did not progress to psychosis (n=37), or were at high risk and did progress to psychosis (n=30). A greedy algorithm process led to selection of five miRNAs that when summed with +1 weights distinguished progressed from nonprogressed subjects with an area under the receiver operating characteristic curve of 0.86. Of the five, miR-941 is human-","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-06-01T00:10:02.04Z","creation":"2025-06-01T00:10:02.04Z"},"accession":"S-EPMC5290334","cross_references":{"pubmed":["27959328"],"doi":["10.1038/tp.2016.148"]}}