biostudies-literatureJeffries CDNIDDK NIH HHSNIMH NIH HHSe981https://www.ebi.ac.uk/biostudies/studies/S-EPMC5290334biostudies-literatureUnknown6(12)Dysregulation of immune system functions has been implicated in schizophrenia, suggesting that immune cells may be involved in the development of the disorder. With the goal of a biomarker assay for psychosis risk, we performed small RNA sequencing on RNA isolated from circulating immune cells. We compared baseline microRNA (miRNA) expression for persons who were unaffected (n=27) or who, over a subsequent 2-year period, were at clinical high risk but did not progress to psychosis (n=37), or were at high risk and did progress to psychosis (n=30). A greedy algorithm process led to selection of five miRNAs that when summed with +1 weights distinguished progressed from nonprogressed subjects with an area under the receiver operating characteristic curve of 0.86. Of the five, miR-941 is human-Translational psychiatryInsights into psychosis risk from leukocyte microRNA expression.PMC5290334U01 MH082022U01 MH082004U01 MH076989U01 MH081928P50 MH066286P30 DK034987R01 MH085521R01 MH076989U01 MH081984U01 MH081902U01 MH081857U01 MH081988U01 MH081944Mathalon DHAddington JBearden CECadenhead KSCornblatt BAWalker EFWoods SWPerkins DOJeffries CDGlatt SJStark TMcGlashan THTsuang MSeidman LJChandler SDYeo ECannon TDfalseInsights into psychosis risk from leukocyte microRNA expression.Dysregulation of immune system functions has been implicated in schizophrenia, suggesting that immune cells may be involved in the development of the disorder. With the goal of a biomarker assay for psychosis risk, we performed small RNA sequencing on RNA isolated from circulating immune cells. We compared baseline microRNA (miRNA) expression for persons who were unaffected (n=27) or who, over a subsequent 2-year period, were at clinical high risk but did not progress to psychosis (n=37), or were at high risk and did progress to psychosis (n=30). A greedy algorithm process led to selection of five miRNAs that when summed with +1 weights distinguished progressed from nonprogressed subjects with an area under the receiver operating characteristic curve of 0.86. Of the five, miR-941 is human-2016-01-01T00:00:00Z2016 Dec2025-06-01T00:10:02.04Z2025-06-01T00:10:02.04ZS-EPMC52903342795932810.1038/tp.2016.148