biostudies-literatureNorberg ENCI NIH HHS251-262https://www.ebi.ac.uk/biostudies/studies/S-EPMC5299709biostudies-literatureUnknown24(2)Diffuse large B-cell lymphomas (DLBCLs) are a highly heterogeneous group of tumors in which subsets share molecular features revealed by gene expression profiles and metabolic fingerprints. While B-cell receptor (BCR)-dependent DLBCLs are glycolytic, OxPhos-DLBCLs rely on mitochondrial energy transduction and nutrient utilization pathways that provide pro-survival benefits independent of BCR signaling. Integral to these metabolic distinctions is elevated mitochondrial electron transport chain (ETC) activity in OxPhos-DLBCLs compared with BCR-DLBCLs, which is linked to greater protein abundance of ETC components. To gain insights into molecular determinants of the selective increase in ETC activity and dependence on mitochondrial energy metabolism in OxPhos-DLBCLs, we examined the mitochondCell death and differentiationDifferential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.PMC5299709R21 CA188881R21 CA178860F31 CA171400Lee SLako ARodig SChapuy BStanley IAChen LMarto JANorberg EChen PHChoi DWShin DShipp MAFicarro SBZhou FDanial NNfalseDifferential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.Diffuse large B-cell lymphomas (DLBCLs) are a highly heterogeneous group of tumors in which subsets share molecular features revealed by gene expression profiles and metabolic fingerprints. While B-cell receptor (BCR)-dependent DLBCLs are glycolytic, OxPhos-DLBCLs rely on mitochondrial energy transduction and nutrient utilization pathways that provide pro-survival benefits independent of BCR signaling. Integral to these metabolic distinctions is elevated mitochondrial electron transport chain (ETC) activity in OxPhos-DLBCLs compared with BCR-DLBCLs, which is linked to greater protein abundance of ETC components. To gain insights into molecular determinants of the selective increase in ETC activity and dependence on mitochondrial energy metabolism in OxPhos-DLBCLs, we examined the mitochond2017-01-01T00:00:00Z2017 Feb2026-05-29T18:15:23.308Z2026-04-08T05:51:04.294ZS-EPMC52997092776812210.1038/cdd.2016.116