{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Echtermeyer A"],"pubmed_abstract":["A recently described C(sp<sup>3</sup>)-H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow. The two approaches are compared in terms of experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model."],"journal":["Beilstein journal of organic chemistry"],"pagination":["150-163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5301945"],"repository":["biostudies-literature"],"pubmed_title":["Self-optimisation and model-based design of experiments for developing a C-H activation flow process."],"pmcid":["PMC5301945"],"pubmed_authors":["Echtermeyer A","Amar Y","Zakrzewski J","Lapkin A"],"additional_accession":[]},"is_claimable":false,"name":"Self-optimisation and model-based design of experiments for developing a C-H activation flow process.","description":"A recently described C(sp<sup>3</sup>)-H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow. The two approaches are compared in terms of experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2022-02-09T09:55:50.475Z","creation":"2019-03-27T02:36:16Z"},"accession":"S-EPMC5301945","cross_references":{"pubmed":["28228856"],"doi":["10.3762/bjoc.13.18"]}}