biostudies-literatureUnknown13Echtermeyer AA recently described C(sp³)-H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow. The two approaches are compared in terms of experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model.Beilstein journal of organic chemistry150-163https://www.ebi.ac.uk/biostudies/studies/S-EPMC5301945biostudies-literatureSelf-optimisation and model-based design of experiments for developing a C-H activation flow process.PMC5301945Echtermeyer AAmar YZakrzewski JLapkin AfalseSelf-optimisation and model-based design of experiments for developing a C-H activation flow process.A recently described C(sp³)-H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow. The two approaches are compared in terms of experimental efficiency. The self-optimisation approach required the least number of experiments to reach the specified objectives of cost and product yield, whereas the MBDoE approach enabled a rapid generation of a process model.2017-01-01T00:00:00Z20172022-02-09T09:55:50.475Z2019-03-27T02:36:16ZS-EPMC53019452822885610.3762/bjoc.13.18