{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Grothe MJ"],"funding":["NIBIB NIH HHS","NIA NIH HHS","CIHR"],"pagination":["569-576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5304459"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(6)"],"pubmed_abstract":["<h4>Objective</h4>To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.<h4>Methods</h4>Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging marker"],"journal":["Neurology"],"pubmed_title":["Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load."],"pmcid":["PMC5304459"],"funding_grant_id":["U24 AG021886","P41 EB015922","U01 AG024904","P50 AG005142","P30 AG010129"],"pubmed_authors":["Crawford K","Carmichael O","Lee VM","Taylor JL","Grossman H","Brewer J","Rosen HJ","Lane B","Chertkow H","DeCarli C","Leon S","Lord JL","Montine T","Villanueva-Meyer J","Wolk D","Taylor-Reinwald L","Petrella JR","Mathis C","Rachinsky I","Frank R","Duara R","Watkins F","Reeder S","de Leon MJ","Celmins D","Wu CK","Pawluczyk S","Romirowsky A","Fletcher E","Lah JJ","DeVous M","Munic D","Salloway S","Karlawish JH","Mintun MA","Turner RS","Capote H","Neu S","Feldman H","Johnson KA","Lee TY","Doraiswamy PM","Bernick C","Preda A","Asthana S","Aisen P","Hosein C","Ott BR","Burns JM","MacAvoy MG","Quinn J","Chaing G","Smith CD","Mintzer J","Bartha DR","Wirth M","Swerdlow RH","Tremont G","Fargher K","Koeppe RA","Varon D","Jicha G","Raudin L","Reynolds B","Kowall N","Green RC","Reiman EM","Dyrba M","Chen K","Brand C","Silverman DH","Bell KL","Carlsson CM","Zimmerman EA","Pomara N","Fleisher A","Sadowsky C","Anderson HS","Porsteinsson AP","Miller BL","Johnson K","Johnson N","Schuff N","Johnson S","Diaz-Arrastia R","Rusinek H","Robin Hsiung GY","Martinez W","Kertesz A","Honig LS","Shah RC","Leyla deToledo-Morrell P","Lerner A","Morris J","Kerwin D","Schultz SK","Lind B","Villena T","Johnson H","Jagust W","Saykin AJ","Gamst A","Dale A","Roberts Cna P","Graff-Radford Mbbch NR","Heidebrink JL","Gessert D","Rosen A","Scharre DW","Albert M","Anderson K","Alzheimer's Disease Neuroimaging Initiative","Apostolova L","Potkin SG","Thompson P","Bandy D","Belden C","Kittur S","Liu E","Schwartz ES","Finger E","Petersen R","Shen L","Kornak J","Budson AE","Clark D","Tinklenberg J","Onyike C","Fox N","Vanderswag H","Ismail MS","Martin K","Sather T","Frey M","Spann BM","Stern Y","Bartzokis G","Kaye J","Sabbagh M","Mitsis E","Norbash A","Trost D","Walter S","Kielb S","Jacobson S","Bernstein M","Killiany R","Molchan S","Kataki M","Cairns NJ","Quiceno M","Drost D","Oakley M","Toga AW","Villeneuve S","Santulli RB","Felmlee J","Shaw L","Longmire CF","Hake AM","Foroud TM","Yesavage J","Schneider S","Weiner M","Snyder PJ","Sarrael A","Blank K","Relkin N","Arnold SE","Sperling RA","Carson RE","Hudson L","Black S","Rainka M","Smith KE","Caldwell C","Pearlson GD","Farlow MR","Mudge B","Beckett L","Carroll M","Jack CR","Herring S","Lopez OL","Mesulam MM","Lipowski K","Dolen S","Wolday S","Foster N","Ogrocki P","van Dyck CH","Boles Ponto LL","Querfurth H","Hernando R","Grothe MJ","Mulnard RA","Stefanovic B","Kachaturian Z","Malloy P","Griffith R","Bates V","Lu PH","Garg P","Mc-Adams-Ortiz C","Marson D","Glodzik L","Simpson DM","Williamson JD","Korecka M","Coleman RE","Harvey D","De Santi S","Correia S","Womack K","Hardy P","Martin-Cook K","Mathews D","Matthews BR","Ances B","Shim H","Doody RS","Chowdhury M","Brown AD","Alexander G","Potkin S","Borrie M","Bergman H","Olichney J","Rogers J","Thai G","Makino KM","King R","Cellar JS","Bwayo SK","Schneider LS","Spicer K","Levey AI","Obisesan TO","Smith A","Trojanowki JQ","Marshall G","Parfitt F","Donohue M","Morris JC","Johnson PL","Bartres-Faz D","Raj BA","Nguyen D","Assaly M","Tariot P","Goldstein BS","Sink KM","Thomas RG"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.","description":"<h4>Objective</h4>To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.<h4>Methods</h4>Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging marker","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-05-04T12:49:10.361Z","creation":"2019-03-26T23:00:27Z"},"accession":"S-EPMC5304459","cross_references":{"pubmed":["28062720"],"doi":["10.1212/WNL.0000000000003585","10.1212/wnl.0000000000003585"]}}