biostudies-literatureGrothe MJNIBIB NIH HHSNIA NIH HHSCIHR569-576https://www.ebi.ac.uk/biostudies/studies/S-EPMC5304459biostudies-literatureUnknown88(6)<h4>Objective</h4>To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.<h4>Methods</h4>Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging markerNeurologyMultimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.PMC5304459U24 AG021886P41 EB015922U01 AG024904P50 AG005142P30 AG010129Crawford KCarmichael OLee VMTaylor JLGrossman HBrewer JRosen HJLane BChertkow HDeCarli CLeon SLord JLMontine TVillanueva-Meyer JWolk DTaylor-Reinwald LPetrella JRMathis CRachinsky IFrank RDuara RWatkins FReeder Sde Leon MJCelmins DWu CKPawluczyk SRomirowsky AFletcher ELah JJDeVous MMunic DSalloway SKarlawish JHMintun MATurner RSCapote HNeu SFeldman HJohnson KALee TYDoraiswamy PMBernick CPreda AAsthana SAisen PHosein COtt BRBurns JMMacAvoy MGQuinn JChaing GSmith CDMintzer JBartha DRWirth MSwerdlow RHTremont GFargher KKoeppe RAVaron DJicha GRaudin LReynolds BKowall NGreen RCReiman EMDyrba MChen KBrand CSilverman DHBell KLCarlsson CMZimmerman EAPomara NFleisher ASadowsky CAnderson HSPorsteinsson APMiller BLJohnson KJohnson NSchuff NJohnson SDiaz-Arrastia RRusinek HRobin Hsiung GYMartinez WKertesz AHonig LSShah RCLeyla deToledo-Morrell PLerner AMorris JKerwin DSchultz SKLind BVillena TJohnson HJagust WSaykin AJGamst ADale ARoberts Cna PGraff-Radford Mbbch NRHeidebrink JLGessert DRosen AScharre DWAlbert MAnderson KAlzheimer's Disease Neuroimaging InitiativeApostolova LPotkin SGThompson PBandy DBelden CKittur SLiu ESchwartz ESFinger EPetersen RShen LKornak JBudson AEClark DTinklenberg JOnyike CFox NVanderswag HIsmail MSMartin KSather TFrey MSpann BMStern YBartzokis GKaye JSabbagh MMitsis ENorbash ATrost DWalter SKielb SJacobson SBernstein MKilliany RMolchan SKataki MCairns NJQuiceno MDrost DOakley MToga AWVilleneuve SSantulli RBFelmlee JShaw LLongmire CFHake AMForoud TMYesavage JSchneider SWeiner MSnyder PJSarrael ABlank KRelkin NArnold SESperling RACarson REHudson LBlack SRainka MSmith KECaldwell CPearlson GDFarlow MRMudge BBeckett LCarroll MJack CRHerring SLopez OLMesulam MMLipowski KDolen SWolday SFoster NOgrocki Pvan Dyck CHBoles Ponto LLQuerfurth HHernando RGrothe MJMulnard RAStefanovic BKachaturian ZMalloy PGriffith RBates VLu PHGarg PMc-Adams-Ortiz CMarson DGlodzik LSimpson DMWilliamson JDKorecka MColeman REHarvey DDe Santi SCorreia SWomack KHardy PMartin-Cook KMathews DMatthews BRAnces BShim HDoody RSChowdhury MBrown ADAlexander GPotkin SBorrie MBergman HOlichney JRogers JThai GMakino KMKing RCellar JSBwayo SKSchneider LSSpicer KLevey AIObisesan TOSmith ATrojanowki JQMarshall GParfitt FDonohue MMorris JCJohnson PLBartres-Faz DRaj BANguyen DAssaly MTariot PGoldstein BSSink KMThomas RGfalseMultimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.<h4>Objective</h4>To comprehensively assess neurobiological effects of the protective APOE2 allele in the aged brain using a cross-sectional multimodal neuroimaging approach.<h4>Methods</h4>Multimodal neuroimaging data were obtained from a total of 572 older individuals without dementia (cognitively normal and mild cognitive impairment) enrolled in the Alzheimer's Disease Neuroimaging Initiative and included assessments of regional amyloid load with AV45-PET, glucose metabolism with fluorodeoxyglucose-PET, and gray matter volume with structural MRI. Imaging indexes of APOE2 carriers were contrasted to risk-neutral APOE3 homozygotes, and analyses were controlled for age, sex, education, and clinical diagnosis. Additional models examined genotype-specific effects of age on the imaging marker2017-01-01T00:00:00Z2017 Feb2026-05-04T12:49:10.361Z2019-03-26T23:00:27ZS-EPMC53044592806272010.1212/WNL.000000000000358510.1212/wnl.0000000000003585