biostudies-literatureDanielak DPolish Ministry of Science and Higher EducationPoznan University of Medical Sciences99-107https://www.ebi.ac.uk/biostudies/studies/S-EPMC5306247biostudies-literatureUnknown42(1)<h4>Background and objectives</h4>Resistance to the antiplatelet treatment with clopidogrel has both genetic and non-genetic causes. Polymorphic variants of cytochrome P450 3A4 isoenzyme involved in the bioactivation of clopidogrel might have an influence on responsiveness to the drug. The aim of this study was to evaluate the influence of CYP3A4*1G (IVS10+12G>A, rs2242480) on the pharmacokinetics and pharmacodynamics of clopidogrel.<h4>Methods</h4>CYP3A4*1G polymorphism was determined in a group of 82 patients undergoing percutaneous coronary intervention and taking 75 mg of clopidogrel daily. Concentrations of clopidogrel and its metabolites, inactive carboxylic acid derivative and two diastereoisomers of active thiol metabolite: H3 and H4, were determined by a validated HPLC-MS/MS methoEuropean journal of drug metabolism and pharmacokineticsImpact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel.PMC5306247502-14-03306413-09628NN 405 419739Karazniewicz-Lada MGlowka FDanielak DKomosa ABergus PWisniewska KBurchardt PfalseImpact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel.<h4>Background and objectives</h4>Resistance to the antiplatelet treatment with clopidogrel has both genetic and non-genetic causes. Polymorphic variants of cytochrome P450 3A4 isoenzyme involved in the bioactivation of clopidogrel might have an influence on responsiveness to the drug. The aim of this study was to evaluate the influence of CYP3A4*1G (IVS10+12G>A, rs2242480) on the pharmacokinetics and pharmacodynamics of clopidogrel.<h4>Methods</h4>CYP3A4*1G polymorphism was determined in a group of 82 patients undergoing percutaneous coronary intervention and taking 75 mg of clopidogrel daily. Concentrations of clopidogrel and its metabolites, inactive carboxylic acid derivative and two diastereoisomers of active thiol metabolite: H3 and H4, were determined by a validated HPLC-MS/MS metho2017-01-01T00:00:00Z2017 Feb2026-07-15T20:58:33.924Z2019-03-27T02:36:24ZS-EPMC53062472689187110.1007/s13318-016-0324-7