{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(38)"],"submitter":["Komatsu S"],"pubmed_abstract":["<h4>Background</h4>This study aims to explore novel microRNAs in plasma for predicting chemoresistance in preoperative chemotherapy of patients with esophageal squamous cell carcinoma (ESCC) using a microRNA array-based approach.<h4>Results</h4>(1) Four candidate microRNAs (miR-223, 103a, 23b and 23a), which were highly expressed in the pretreatment plasma of patients with a low histopathologic response, were selected. (2) In a large-scale validation analysis by quantitative RT-PCR, plasma levels of miR-223, miR-23b and miR-23a were significantly higher in patients with a low histopathologic response than in those with a high histopathologic response (p = 0.0345, p = 0.0125 and p = 0.0114). (3) Of all candidate microRNAs, miR-23a expression of pretreatment ESCC tumor tissues was significan"],"journal":["Oncotarget"],"pagination":["62034-62048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5308709"],"repository":["biostudies-literature"],"pubmed_title":["Plasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma."],"pmcid":["PMC5308709"],"pubmed_authors":["Arita T","Otsuji E","Komatsu S","Shiozaki A","Kiuchi J","Okamoto K","Kawaguchi T","Ichikawa D","Miyamae M","Fujiwara H","Imamura T","Takeshita H","Ohashi T","Konishi H","Okajima W"],"additional_accession":[]},"is_claimable":false,"name":"Plasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma.","description":"<h4>Background</h4>This study aims to explore novel microRNAs in plasma for predicting chemoresistance in preoperative chemotherapy of patients with esophageal squamous cell carcinoma (ESCC) using a microRNA array-based approach.<h4>Results</h4>(1) Four candidate microRNAs (miR-223, 103a, 23b and 23a), which were highly expressed in the pretreatment plasma of patients with a low histopathologic response, were selected. (2) In a large-scale validation analysis by quantitative RT-PCR, plasma levels of miR-223, miR-23b and miR-23a were significantly higher in patients with a low histopathologic response than in those with a high histopathologic response (p = 0.0345, p = 0.0125 and p = 0.0114). (3) Of all candidate microRNAs, miR-23a expression of pretreatment ESCC tumor tissues was significan","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-04-05T15:33:15.027Z","creation":"2019-03-27T02:36:28Z"},"accession":"S-EPMC5308709","cross_references":{"pubmed":["27566562"],"doi":["10.18632/oncotarget.11500"]}}