biostudies-literatureUnknown7(38)Komatsu S<h4>Background</h4>This study aims to explore novel microRNAs in plasma for predicting chemoresistance in preoperative chemotherapy of patients with esophageal squamous cell carcinoma (ESCC) using a microRNA array-based approach.<h4>Results</h4>(1) Four candidate microRNAs (miR-223, 103a, 23b and 23a), which were highly expressed in the pretreatment plasma of patients with a low histopathologic response, were selected. (2) In a large-scale validation analysis by quantitative RT-PCR, plasma levels of miR-223, miR-23b and miR-23a were significantly higher in patients with a low histopathologic response than in those with a high histopathologic response (p = 0.0345, p = 0.0125 and p = 0.0114). (3) Of all candidate microRNAs, miR-23a expression of pretreatment ESCC tumor tissues was significanOncotarget62034-62048https://www.ebi.ac.uk/biostudies/studies/S-EPMC5308709biostudies-literaturePlasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma.PMC5308709Arita TOtsuji EKomatsu SShiozaki AKiuchi JOkamoto KKawaguchi TIchikawa DMiyamae MFujiwara HImamura TTakeshita HOhashi TKonishi HOkajima WfalsePlasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma.<h4>Background</h4>This study aims to explore novel microRNAs in plasma for predicting chemoresistance in preoperative chemotherapy of patients with esophageal squamous cell carcinoma (ESCC) using a microRNA array-based approach.<h4>Results</h4>(1) Four candidate microRNAs (miR-223, 103a, 23b and 23a), which were highly expressed in the pretreatment plasma of patients with a low histopathologic response, were selected. (2) In a large-scale validation analysis by quantitative RT-PCR, plasma levels of miR-223, miR-23b and miR-23a were significantly higher in patients with a low histopathologic response than in those with a high histopathologic response (p = 0.0345, p = 0.0125 and p = 0.0114). (3) Of all candidate microRNAs, miR-23a expression of pretreatment ESCC tumor tissues was significan2016-01-01T00:00:00Z2016 Sep2025-04-05T15:33:15.027Z2019-03-27T02:36:28ZS-EPMC53087092756656210.18632/oncotarget.11500