{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luan L"],"funding":["National Institute of Neurological Disorders and Stroke","UT Austin Cockrell School of Engineering","the Office of the Assistant Secretary of Defense for Health Affairs","NIBIB NIH HHS","the University of Texas System Neuroscience and Neurotechnology Research Institute","NINDS NIH HHS"],"pagination":["e1601966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5310823"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(2)"],"pubmed_abstract":["Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks,"],"journal":["Science advances"],"pubmed_title":["Ultraflexible nanoelectronic probes form reliable, glial scar-free neural integration."],"pmcid":["PMC5310823"],"funding_grant_id":["ID0EVXBK15131","ID0EOTBK15130","R01 EB011556","W81XWH-16-1-0580","ID0EBGBK15129","Start-up fund","R01EB011556","ID0ENQAK15127","ID0E14AK15128","365459","R01 NS082518","R01NS082518"],"pubmed_authors":["Holloway S","Lin S","Siegel JJ","Fowler RA","Wei X","Luan L","Tuppen CA","Zhao Z","Kazmi S","Potnis O","Dunn AK","Chitwood RA","Xie C"],"additional_accession":[]},"is_claimable":false,"name":"Ultraflexible nanoelectronic probes form reliable, glial scar-free neural integration.","description":"Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks,","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-26T12:12:05.487Z","creation":"2019-03-26T23:22:04Z"},"accession":"S-EPMC5310823","cross_references":{"pubmed":["28246640"],"doi":["10.1126/sciadv.1601966"]}}