biostudies-literatureNkuipou-Kenfack EMathilde-Wagner-HabilitationspreisBMBF Gerontosys II prpjectExcellence Initiative of the German Federal and State GovernmentsEuropean Research CouncilBMBF-STOP-FSGSMargarete von Wrangell HabilitationsprogrammEU FP7Heisenberg programGerman Research Foundation (DFG)e0166875https://www.ebi.ac.uk/biostudies/studies/S-EPMC5310860biostudies-literatureUnknown12(2)Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS). Using age as a continuous variable, 295 peptides significantly correlated with age in micPloS oneThe use of urinary proteomics in the assessment of suitability of mouse models for ageing.PMC5310860Mathilde-Wagner-HabilitationspreisCIG-293568616891CodeAge-31354Heisenberg program01GM1518CEXC294NephAge-031 5896AMinisterium für Wissenschaft Baden-WürttembergCRC-992Huber TBBajwa SKoeck TPich APejchinovski MVinel CBusch HRudolph KLNkuipou-Kenfack ESchanstra JPBechtel-Walz WDray CBascands JLZurbig PBorries MMischak HVlahou AValet PfalseThe use of urinary proteomics in the assessment of suitability of mouse models for ageing.Ageing is a complex process characterised by a systemic and progressive deterioration of biological functions. As ageing is associated with an increased prevalence of age-related chronic disorders, understanding its underlying molecular mechanisms can pave the way for therapeutic interventions and managing complications. Animal models such as mice are commonly used in ageing research as they have a shorter lifespan in comparison to humans and are also genetically close to humans. To assess the translatability of mouse ageing to human ageing, the urinary proteome in 89 wild-type (C57BL/6) mice aged between 8-96 weeks was investigated using capillary electrophoresis coupled to mass spectrometry (CE-MS). Using age as a continuous variable, 295 peptides significantly correlated with age in mic2017-01-01T00:00:00Z20172026-04-07T14:43:40.051Z2019-03-26T22:52:54ZS-EPMC53108602819932010.1371/journal.pone.0166875