{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilson JA"],"funding":["Queensland Government","University of Queensland","National Health and Medical Research Council (AU)","Programme d'Investissements d'Avenir'","Queensland Tropical Health Alliance"],"pagination":["e1006155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5312928"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7) and chronic disease (day 30) in the CHIKV adult wild-type mouse model. Genes previously shown to be up-regulated in CHIKV patients were also up-regulated in the mouse model. CHIKV sequence information was also obtained with up to ≈8% of the reads mapping to the viral genome; however, no adaptive viral genome changes were apparent. Although day 2, 7 and 30 represent distinct stages of infection and disease, there was a pronounced overlap in up-regulated host genes and pathways. Type I interferon response genes (IRGs) represented up to ≈50%"],"journal":["PLoS pathogens"],"pubmed_title":["RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation."],"pmcid":["PMC5312928"],"funding_grant_id":["Principal Research Fellow","ANR-11-INBS-0008; Intergrated Chikungunya Research project 261202","Australian Postgraduate Award","Advance Queensland Research Fellowship","BSL3 equipment","APP613622"],"pubmed_authors":["Prow NA","Ellis JJ","Suhrbier A","Tang B","Gearing LJ","Gardner J","Wilson JA","Schroder WA","Hueston L","Le Grand R","Mahalingam S","Roques P","Poo YS","Le TT","Taylor A","Hertzog PJ","Bird PI","Cumming HE","Di Giallonardo F"],"additional_accession":[]},"is_claimable":false,"name":"RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.","description":"Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7) and chronic disease (day 30) in the CHIKV adult wild-type mouse model. Genes previously shown to be up-regulated in CHIKV patients were also up-regulated in the mouse model. CHIKV sequence information was also obtained with up to ≈8% of the reads mapping to the viral genome; however, no adaptive viral genome changes were apparent. Although day 2, 7 and 30 represent distinct stages of infection and disease, there was a pronounced overlap in up-regulated host genes and pathways. Type I interferon response genes (IRGs) represented up to ≈50%","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2026-05-04T20:12:08.779Z","creation":"2019-03-26T22:49:14Z"},"accession":"S-EPMC5312928","cross_references":{"pubmed":["28207896"],"doi":["10.1371/journal.ppat.1006155"]}}