{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Prylutska S"],"pubmed_abstract":["Dimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, <sup>1</sup>H, and <sup>31</sup>P NMR spectroscopy. In vitro HL1 and HL2 at 1 mM concentration caused cell specific and time-dependent decrease of leukemic cell viability. Compounds caused the similar gradual decrease of Jurkat cells viability at 72 h (by 35%). HL1 had earlier and more profound toxic effect as compared to HL2 regardless on leukemic cell line. Viability of Molt-16 and CCRF-CEM cells under the action of HL1 was decreased at 24 h (by 32 and 45%, respectively) with no substantial further reducing up to 72 h. Toxic effect of HL2 was detected only at 72 h of incubation of Jurkat and M"],"journal":["Nanoscale research letters"],"pagination":["124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5315654"],"repository":["biostudies-literature"],"pubmed_title":["Cytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C<sub>60</sub> Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA."],"pmcid":["PMC5315654"],"pubmed_authors":["Hurmach V","Sliva T","Shatrava I","Prylutskyy Y","Grebinyk A","Frohme M","Slobodyanik M","Matyshevska O","Ritter U","Prylutska S","Amirkhanov V","Grynyuk I"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C<sub>60</sub> Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA.","description":"Dimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, <sup>1</sup>H, and <sup>31</sup>P NMR spectroscopy. In vitro HL1 and HL2 at 1 mM concentration caused cell specific and time-dependent decrease of leukemic cell viability. Compounds caused the similar gradual decrease of Jurkat cells viability at 72 h (by 35%). HL1 had earlier and more profound toxic effect as compared to HL2 regardless on leukemic cell line. Viability of Molt-16 and CCRF-CEM cells under the action of HL1 was decreased at 24 h (by 32 and 45%, respectively) with no substantial further reducing up to 72 h. Toxic effect of HL2 was detected only at 72 h of incubation of Jurkat and M","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-18T14:38:07.81Z","creation":"2019-03-27T02:36:50Z"},"accession":"S-EPMC5315654","cross_references":{"pubmed":["28235359"],"doi":["10.1186/s11671-017-1893-3"]}}