biostudies-literatureUnknown12(1)Prylutska SDimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, ¹H, and ³¹P NMR spectroscopy. In vitro HL1 and HL2 at 1 mM concentration caused cell specific and time-dependent decrease of leukemic cell viability. Compounds caused the similar gradual decrease of Jurkat cells viability at 72 h (by 35%). HL1 had earlier and more profound toxic effect as compared to HL2 regardless on leukemic cell line. Viability of Molt-16 and CCRF-CEM cells under the action of HL1 was decreased at 24 h (by 32 and 45%, respectively) with no substantial further reducing up to 72 h. Toxic effect of HL2 was detected only at 72 h of incubation of Jurkat and MNanoscale research letters124https://www.ebi.ac.uk/biostudies/studies/S-EPMC5315654biostudies-literatureCytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C₆₀ Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA.PMC5315654Hurmach VSliva TShatrava IPrylutskyy YGrebinyk AFrohme MSlobodyanik MMatyshevska ORitter UPrylutska SAmirkhanov VGrynyuk IfalseCytotoxic Effects of Dimorfolido-N-Trichloroacetylphosphorylamide and Dimorfolido-N-Benzoylphosphorylamide in Combination with C₆₀ Fullerene on Leukemic Cells and Docking Study of Their Interaction with DNA.Dimorfolido-N-trichloroacetylphosphorylamide (HL1) and dimorfolido-N-benzoylphosphorylamide (HL2) as representatives of carbacylamidophosphates were synthesized and identified by the methods of IR, ¹H, and ³¹P NMR spectroscopy. In vitro HL1 and HL2 at 1 mM concentration caused cell specific and time-dependent decrease of leukemic cell viability. Compounds caused the similar gradual decrease of Jurkat cells viability at 72 h (by 35%). HL1 had earlier and more profound toxic effect as compared to HL2 regardless on leukemic cell line. Viability of Molt-16 and CCRF-CEM cells under the action of HL1 was decreased at 24 h (by 32 and 45%, respectively) with no substantial further reducing up to 72 h. Toxic effect of HL2 was detected only at 72 h of incubation of Jurkat and M2017-01-01T00:00:00Z2017 Dec2025-04-18T14:38:07.81Z2019-03-27T02:36:50ZS-EPMC53156542823535910.1186/s11671-017-1893-3