{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu K"],"funding":["National Natural Science Foundation of China"],"pagination":["5830971"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5317119"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2017"],"pubmed_abstract":["Previous transcriptomic analysis revealed a 393-transcript signature (PTBsig), which is dominated by interferon inducible genes, in whole blood of pulmonary tuberculosis (PTB) patients. Comparisons with a limited set of interferon-driven genes among separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils indicated that the signature is due to changes in neutrophils, the overwhelmingly predominant cell type. By extending the analysis to the entire 393 transcripts of PTBsig and by switching the cell proportions between separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils, we create putative PTBsig for whole blood (pPTBsig) in which CD4+ or CD8+ T cells or monocytes predominated or in which the cell proportions were unchanged. These putative signatures are then compared t"],"journal":["International journal of genomics"],"pubmed_title":["The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature."],"pmcid":["PMC5317119"],"funding_grant_id":["81273328","81301407","12531781","81371777"],"pubmed_authors":["Wu K","Fan XY","Li J","Lowrie DB","Deng WL","Zhang H","Wong KW"],"additional_accession":[]},"is_claimable":false,"name":"The Numerical Predominance and Large Transcriptome Differences of Neutrophils in Peripheral Blood Together Inevitably Account for a Reported Pulmonary Tuberculosis Signature.","description":"Previous transcriptomic analysis revealed a 393-transcript signature (PTBsig), which is dominated by interferon inducible genes, in whole blood of pulmonary tuberculosis (PTB) patients. Comparisons with a limited set of interferon-driven genes among separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils indicated that the signature is due to changes in neutrophils, the overwhelmingly predominant cell type. By extending the analysis to the entire 393 transcripts of PTBsig and by switching the cell proportions between separated monocytes, CD4+ T cells, CD8+ T cells, and neutrophils, we create putative PTBsig for whole blood (pPTBsig) in which CD4+ or CD8+ T cells or monocytes predominated or in which the cell proportions were unchanged. These putative signatures are then compared t","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-18T17:43:47.54Z","creation":"2019-03-27T02:36:55Z"},"accession":"S-EPMC5317119","cross_references":{"pubmed":["28265564"],"doi":["10.1155/2017/5830971"]}}