{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Tripathy SN"],"pubmed_abstract":["Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propose a novel thermodynamic path to prepare a high density amorphous state of matter (carvedilol dihydrogen phosphate) using high pressure. In addition, we provide the impeccable experimental evidence of heterogeneous nature of secondary β-relaxation and probe its properties to understand the various aspects of pressure densified glass, such as dynamics, packing and disorder. These features are expected to provide new horizons to glass preparation and functional response to pharmaceutical applications."],"journal":["Scientific reports"],"pagination":["43091"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5320533"],"repository":["biostudies-literature"],"pubmed_title":["New limits of secondary β-relaxation."],"pmcid":["PMC5320533"],"pubmed_authors":["Knapik-Kowalczuk J","Tripathy SN","Wojnarowska Z","Rams-Baron M","Paluch M"],"additional_accession":[]},"is_claimable":false,"name":"New limits of secondary β-relaxation.","description":"Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propose a novel thermodynamic path to prepare a high density amorphous state of matter (carvedilol dihydrogen phosphate) using high pressure. In addition, we provide the impeccable experimental evidence of heterogeneous nature of secondary β-relaxation and probe its properties to understand the various aspects of pressure densified glass, such as dynamics, packing and disorder. These features are expected to provide new horizons to glass preparation and functional response to pharmaceutical applications.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Feb","modification":"2025-04-18T19:20:51.793Z","creation":"2019-03-27T02:37:03Z"},"accession":"S-EPMC5320533","cross_references":{"pubmed":["28225060"],"doi":["10.1038/srep43091"]}}