{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nfonsam V"],"funding":["NCI NIH HHS"],"pagination":["1005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5321608"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(1)"],"pubmed_abstract":["<h4>Background</h4>Overall declines in incidence of rectal cancer (RC) in patients older than 50 years have been mostly attributed to improvement in treatment modalities and introduction of age-based screening. Recent studies, however, have shown a rise in the incidence of RC in patients younger than 50 years. The etiology of early-onset (EO) RC is not well understood. The aim of this study is to elucidate the molecular features of (EO) RC and show its uniqueness compared to late-onset (LO) disease.<h4>Methods</h4>Two cohorts of patients with sporadic RC were identified. Tumors and matching non-involved tissues from six (EO) RC patients (< 50 years) and six (LO) RC patients (>65 years) were obtained from Pathology archives. Deparaffinized tissues were macro-dissected from FFPE sections, RN"],"journal":["Gastrointestinal cancer : research & therapy"],"pubmed_title":["Gene Expression Analysis of Sporadic Early-Onset Rectal Adenocarcinoma."],"pmcid":["PMC5321608"],"funding_grant_id":["P30 CA023074"],"pubmed_authors":["Nfonsam V","Jandova J","Koblinski J","Xu W"],"additional_accession":[]},"is_claimable":false,"name":"Gene Expression Analysis of Sporadic Early-Onset Rectal Adenocarcinoma.","description":"<h4>Background</h4>Overall declines in incidence of rectal cancer (RC) in patients older than 50 years have been mostly attributed to improvement in treatment modalities and introduction of age-based screening. Recent studies, however, have shown a rise in the incidence of RC in patients younger than 50 years. The etiology of early-onset (EO) RC is not well understood. The aim of this study is to elucidate the molecular features of (EO) RC and show its uniqueness compared to late-onset (LO) disease.<h4>Methods</h4>Two cohorts of patients with sporadic RC were identified. Tumors and matching non-involved tissues from six (EO) RC patients (< 50 years) and six (LO) RC patients (>65 years) were obtained from Pathology archives. Deparaffinized tissues were macro-dissected from FFPE sections, RN","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-04T02:09:15.574Z","creation":"2019-03-27T02:37:07Z"},"accession":"S-EPMC5321608","cross_references":{"pubmed":["28239680"]}}