biostudies-literatureNfonsam VNCI NIH HHS1005https://www.ebi.ac.uk/biostudies/studies/S-EPMC5321608biostudies-literatureUnknown1(1)<h4>Background</h4>Overall declines in incidence of rectal cancer (RC) in patients older than 50 years have been mostly attributed to improvement in treatment modalities and introduction of age-based screening. Recent studies, however, have shown a rise in the incidence of RC in patients younger than 50 years. The etiology of early-onset (EO) RC is not well understood. The aim of this study is to elucidate the molecular features of (EO) RC and show its uniqueness compared to late-onset (LO) disease.<h4>Methods</h4>Two cohorts of patients with sporadic RC were identified. Tumors and matching non-involved tissues from six (EO) RC patients (< 50 years) and six (LO) RC patients (>65 years) were obtained from Pathology archives. Deparaffinized tissues were macro-dissected from FFPE sections, RNGastrointestinal cancer : research & therapyGene Expression Analysis of Sporadic Early-Onset Rectal Adenocarcinoma.PMC5321608P30 CA023074Nfonsam VJandova JKoblinski JXu WfalseGene Expression Analysis of Sporadic Early-Onset Rectal Adenocarcinoma.<h4>Background</h4>Overall declines in incidence of rectal cancer (RC) in patients older than 50 years have been mostly attributed to improvement in treatment modalities and introduction of age-based screening. Recent studies, however, have shown a rise in the incidence of RC in patients younger than 50 years. The etiology of early-onset (EO) RC is not well understood. The aim of this study is to elucidate the molecular features of (EO) RC and show its uniqueness compared to late-onset (LO) disease.<h4>Methods</h4>Two cohorts of patients with sporadic RC were identified. Tumors and matching non-involved tissues from six (EO) RC patients (< 50 years) and six (LO) RC patients (>65 years) were obtained from Pathology archives. Deparaffinized tissues were macro-dissected from FFPE sections, RN2016-01-01T00:00:00Z20162025-04-04T02:09:15.574Z2019-03-27T02:37:07ZS-EPMC532160828239680