{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["van Rensburg IC"],"pubmed_abstract":["<h4>Introduction</h4>Studies show that B-cells, in addition to producing antibodies and antigen-presentation, are able to produce cytokines as well. These include regulatory cytokines such as IL-10 by regulatory B-cells. Furthermore, a rare regulatory subset of B-cells have the potential to express FasL, which is a death-inducing ligand. This subset of B-cells have a positive role during autoimmune disease, but has not yet been studied during tuberculosis. These FasL-expressing B-cells are induced by bacterial LPS and CpG, thus we hypothesized that this phenotype might be induced during tuberculosis as well.<h4>Methods</h4>B-cells from participants with TB (at diagnosis and during treatment) and controls were collected, and analyzed by means of real-time PCR and flow cytometry. In addition"],"journal":["Immunity, inflammation and disease"],"pagination":["57-67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5322165"],"repository":["biostudies-literature"],"pubmed_title":["B-cells with a FasL expressing regulatory phenotype are induced following successful anti-tuberculosis treatment."],"pmcid":["PMC5322165"],"pubmed_authors":["Walzl G","Loxton AG","Kleynhans L","van Rensburg IC","Keyser A"],"additional_accession":[]},"is_claimable":false,"name":"B-cells with a FasL expressing regulatory phenotype are induced following successful anti-tuberculosis treatment.","description":"<h4>Introduction</h4>Studies show that B-cells, in addition to producing antibodies and antigen-presentation, are able to produce cytokines as well. These include regulatory cytokines such as IL-10 by regulatory B-cells. Furthermore, a rare regulatory subset of B-cells have the potential to express FasL, which is a death-inducing ligand. This subset of B-cells have a positive role during autoimmune disease, but has not yet been studied during tuberculosis. These FasL-expressing B-cells are induced by bacterial LPS and CpG, thus we hypothesized that this phenotype might be induced during tuberculosis as well.<h4>Methods</h4>B-cells from participants with TB (at diagnosis and during treatment) and controls were collected, and analyzed by means of real-time PCR and flow cytometry. In addition","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2025-04-18T19:23:13.623Z","creation":"2019-03-26T23:41:24Z"},"accession":"S-EPMC5322165","cross_references":{"pubmed":["28250925"],"doi":["10.1002/iid3.140"]}}