{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hong YM"],"funding":["National Research Foundation of Korea"],"pagination":["7982389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5322441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2017"],"pubmed_abstract":["In a previous study, we found that the short isoform of DNAJB6 (DNAJB6(S)) had been decreased in the striatum of a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). DNAJB6, one of the heat shock proteins, has been implicated in the pathogenesis of PD. In this study, we explored the cytoprotective effect of DNAJB6(S) against 1-methyl-4-phenylpyridinium ion- (MPP<sup>+</sup>-) induced apoptosis and the underlying molecular mechanisms in cultured LN18 cells from astrocytic tumors. We observed that MPP<sup>+</sup> significantly reduced the cell viability and induced apoptosis in LN18 glioblastoma cells. DNAJB6(S) protected LN18 cells against MPP<sup>+</sup>-induced apoptosis not only by suppressing Bax cleavage but also by inhibiting a seri"],"journal":["Oxidative medicine and cellular longevity"],"pubmed_title":["The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss."],"pmcid":["PMC5322441"],"funding_grant_id":["NRF-2014R1A2A1A11052795"],"pubmed_authors":["Yeo S","Lim S","Hong Y","Jin SH","Lee SW","Jung H","Lee SH","Choi YG","Sung B","Hong YM"],"additional_accession":[]},"is_claimable":false,"name":"The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss.","description":"In a previous study, we found that the short isoform of DNAJB6 (DNAJB6(S)) had been decreased in the striatum of a mouse model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). DNAJB6, one of the heat shock proteins, has been implicated in the pathogenesis of PD. In this study, we explored the cytoprotective effect of DNAJB6(S) against 1-methyl-4-phenylpyridinium ion- (MPP<sup>+</sup>-) induced apoptosis and the underlying molecular mechanisms in cultured LN18 cells from astrocytic tumors. We observed that MPP<sup>+</sup> significantly reduced the cell viability and induced apoptosis in LN18 glioblastoma cells. DNAJB6(S) protected LN18 cells against MPP<sup>+</sup>-induced apoptosis not only by suppressing Bax cleavage but also by inhibiting a seri","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-18T19:22:48.779Z","creation":"2019-03-27T02:37:11Z"},"accession":"S-EPMC5322441","cross_references":{"pubmed":["28280525"],"doi":["10.1155/2017/7982389"]}}