biostudies-literatureSheu MJChung Shan Medical University Hospital and Chi-Mei Foundation Medical CenterMinistry of Science and Technology,e0172506https://www.ebi.ac.uk/biostudies/studies/S-EPMC5322915biostudies-literatureUnknown12(2)<h4>Background</h4>ADAMTS14 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs), which are proteolytic enzymes with a variety of further ancillary domain in the C-terminal region for substrate specificity and enzyme localization via extracellular matrix association. However, whether ADAMTS14 genetic variants play a role in hepatocellular carcinoma (HCC) susceptibility remains unknown.<h4>Methodology/principal findings</h4>Four non-synonymous single-nucleotide polymorphisms (nsSNPs) of the ADAMTS14 gene were examined from 680 controls and 340 patients with HCC. Among 141 HCC patients with smoking behaviour, we found significant associations of the rs12774070 (CC+AA vs CC) and rs61573157 (CT+TT vs CC) variants with a clinical stage of HCC (OR: 2.500 andPloS oneEffects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma.PMC5322915NSC-102-2320-B-040-012-MY2CSMU-CMMC-105-05Hsieh MJWang PHLee HLLiu YFSheu MJChou YEYang SFYeh CBfalseEffects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma.<h4>Background</h4>ADAMTS14 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs), which are proteolytic enzymes with a variety of further ancillary domain in the C-terminal region for substrate specificity and enzyme localization via extracellular matrix association. However, whether ADAMTS14 genetic variants play a role in hepatocellular carcinoma (HCC) susceptibility remains unknown.<h4>Methodology/principal findings</h4>Four non-synonymous single-nucleotide polymorphisms (nsSNPs) of the ADAMTS14 gene were examined from 680 controls and 340 patients with HCC. Among 141 HCC patients with smoking behaviour, we found significant associations of the rs12774070 (CC+AA vs CC) and rs61573157 (CT+TT vs CC) variants with a clinical stage of HCC (OR: 2.500 and2017-01-01T00:00:00Z20172026-05-30T06:45:21.192Z2019-03-26T22:52:55ZS-EPMC53229152823130610.1371/journal.pone.0172506