{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loupe JM"],"funding":["NIMHD NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["62814-62835"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5325330"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(39)"],"pubmed_abstract":["While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not clear whether it is the cause or effect of malignant transformation. The childhood sarcoma, Alveolar Rhabdomyosarcoma (ARMS), is primarily defined by the t(2;13)(q35;q14) translocation, creating the PAX3-FOXO1 fusion protein. It is unclear what role PAX3-FOXO1 plays in the initial stages of tumor development through the acquisition and persistence of aneuploidy. In this study we demonstrate that PAX3-FOXO1 serves as a driver mutation to initiate a cascade of mRNA and miRNA changes that ultimately "],"journal":["Oncotarget"],"pubmed_title":["Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects."],"pmcid":["PMC5325330"],"funding_grant_id":["R01 CA138656","P20 GM103501","P30 GM114732","U54 GM104940","P20 MD004817","U54 MD008176"],"pubmed_authors":["Loupe JM","Miller PJ","Vijayaraghavan J","Crabtree JS","Taylor CM","Zabaleta J","Tsien F","Bonner BP","Hollenbach AD","Maggi EC"],"additional_accession":[]},"is_claimable":false,"name":"Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects.","description":"While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not clear whether it is the cause or effect of malignant transformation. The childhood sarcoma, Alveolar Rhabdomyosarcoma (ARMS), is primarily defined by the t(2;13)(q35;q14) translocation, creating the PAX3-FOXO1 fusion protein. It is unclear what role PAX3-FOXO1 plays in the initial stages of tumor development through the acquisition and persistence of aneuploidy. In this study we demonstrate that PAX3-FOXO1 serves as a driver mutation to initiate a cascade of mRNA and miRNA changes that ultimately ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Sep","modification":"2025-05-29T20:05:03.295Z","creation":"2025-05-29T20:05:03.295Z"},"accession":"S-EPMC5325330","cross_references":{"pubmed":["27588498"],"doi":["10.18632/oncotarget.11716"]}}