biostudies-literatureUnknown7(3)Martinho OPersistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic marker for these patients. By using <i>in vitro</i> and <i>in vivo</i> approaches, we provided evidence that HER inhibitors, allitinib and lapatinib, were effective in reducing cervical cancer aggressiveness. Furthermore, combination of these drugs with glucose uptake blockers could overcome the putative HIF1-α-mediated resistance to HER-targeted therapies. Thus, we propose that theTheranostics717-732https://www.ebi.ac.uk/biostudies/studies/S-EPMC5327645biostudies-literatureHER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.PMC5327645Miranda-Goncalves VSilva-Oliveira RZanon MReis RMScapulatempo-Neto CBaltazar FBarbosa AMMoreira MACury FPMarques FCardoso-Carneiro DMartinho OEvangelista AFde Paula FELongatto-Filho AGranja SfalseHER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.Persistent HPV infection alone is not sufficient for cervical cancer development, which requires additional molecular alterations for tumor progression and metastasis ultimately leading to a lethal disease. In this study, we performed a comprehensive analysis of HER family receptor alterations in cervical adenocarcinoma. We detected overexpression of HER protein, mainly HER2, which was an independent prognostic marker for these patients. By using <i>in vitro</i> and <i>in vivo</i> approaches, we provided evidence that HER inhibitors, allitinib and lapatinib, were effective in reducing cervical cancer aggressiveness. Furthermore, combination of these drugs with glucose uptake blockers could overcome the putative HIF1-α-mediated resistance to HER-targeted therapies. Thus, we propose that the2017-01-01T00:00:00Z20172025-04-04T09:00:24.837Z2019-03-27T02:37:26ZS-EPMC53276452825536210.7150/thno.17154