biostudies-literatureIslam SUniversity Grants CommissionCouncil of Scientific and Industrial Research, Government of Indiae0172760https://www.ebi.ac.uk/biostudies/studies/S-EPMC5330495biostudies-literatureUnknown12(2)<h4>Objectives</h4>Human papillomavirus (HPV) causes tumors primarily Cervical cancer. Recently, inconsistent reports came up in Breast cancer (BC) too. In India, despite treatment 70,218 BC patients die each year. So, we explored the association of HPV, if any, with BC prognosis in Indian pre-therapeutic (PT) and Neo-adjuvant chemotherapy (NACT) patients with subsequent analysis of HPV profile.<h4>Methods</h4>HPV prevalence was checked and analysis of physical status, copy number, genome variation, promoter methylation and expression (mRNA and protein) of the prevalent subtype was done.<h4>Results</h4>High prevalence of HPV was observed in both PT (64.0%) and NACT (71.0%) cases with significant association with younger (20-45 yrs) PT patients. Interestingly, HPV infection was significantlPloS oneStudy of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication.PMC5330495F.2-3/2000 (SA-I) (Sr. No. 2061030813, Ref. No.: 20-06 / 201060(0111)/14/EMR-II of dt 03/11/2014Dasgupta HIslam SMandal SPanda CKMukherjee NBiswas JBhattacharya RRoy ARoychowdhury AMandal GKAlam NRoychoudhury SfalseStudy of association and molecular analysis of human papillomavirus in breast cancer of Indian patients: Clinical and prognostic implication.<h4>Objectives</h4>Human papillomavirus (HPV) causes tumors primarily Cervical cancer. Recently, inconsistent reports came up in Breast cancer (BC) too. In India, despite treatment 70,218 BC patients die each year. So, we explored the association of HPV, if any, with BC prognosis in Indian pre-therapeutic (PT) and Neo-adjuvant chemotherapy (NACT) patients with subsequent analysis of HPV profile.<h4>Methods</h4>HPV prevalence was checked and analysis of physical status, copy number, genome variation, promoter methylation and expression (mRNA and protein) of the prevalent subtype was done.<h4>Results</h4>High prevalence of HPV was observed in both PT (64.0%) and NACT (71.0%) cases with significant association with younger (20-45 yrs) PT patients. Interestingly, HPV infection was significantl2017-01-01T00:00:00Z20172026-05-05T19:38:46.716Z2019-03-26T22:52:56ZS-EPMC53304952824528710.1371/journal.pone.0172760