{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(3)"],"submitter":["Mastroianno S"],"pubmed_abstract":["<h4>Background</h4>Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.<h4>Objectives</h4>To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.<h4>Materials and methods</h4>258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.<h4>Results</h4>As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total perip"],"journal":["PloS one"],"pagination":["e0171055"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5332070"],"repository":["biostudies-literature"],"pubmed_title":["Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy."],"pmcid":["PMC5332070"],"pubmed_authors":["Paroni G","Di Stolfo G","Seripa D","Urbano M","Greco A","Gravina C","d'Arienzo C","Coli C","Pacilli MA","Mastroianno S","De Luca G","Russo A","Potenza DR"],"additional_accession":[]},"is_claimable":false,"name":"Role of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.","description":"<h4>Background</h4>Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.<h4>Objectives</h4>To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.<h4>Materials and methods</h4>258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.<h4>Results</h4>As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total perip","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-18T23:36:15.737Z","creation":"2019-03-26T22:49:19Z"},"accession":"S-EPMC5332070","cross_references":{"pubmed":["28249002"],"doi":["10.1371/journal.pone.0171055"]}}