biostudies-literatureUnknown12(3)Mastroianno S<h4>Background</h4>Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.<h4>Objectives</h4>To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.<h4>Materials and methods</h4>258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.<h4>Results</h4>As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total peripPloS onee0171055https://www.ebi.ac.uk/biostudies/studies/S-EPMC5332070biostudies-literatureRole of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.PMC5332070Paroni GDi Stolfo GSeripa DUrbano MGreco AGravina Cd'Arienzo CColi CPacilli MAMastroianno SDe Luca GRusso APotenza DRfalseRole of the APOE polymorphism in carotid and lower limb revascularization: A prospective study from Southern Italy.<h4>Background</h4>Atherosclerosis is a complex multifactorial disease and the apolipoprotein E (APOE) polymorphism has been associated to vascular complications of atherosclerosis.<h4>Objectives</h4>To investigate the relationship between the APOE genotypes and advanced peripheral vascular disease.<h4>Materials and methods</h4>258 consecutive patients (201 males and 57 females, mean age 70.83 ± 7.89 years) with severe PVD were enrolled in a 42-months longitudinal study (mean 31.65 ± 21.11 months) for major adverse cardiovascular events. At follow-up genotypes of the APOE polymorphism were investigated in blinded fashion.<h4>Results</h4>As compared with ε3/ε3, in ε4-carriers a significant higher incidence of major adverse cardiovascular events (35.58% vs. 20.79%; p = 0.025) and total perip2017-01-01T00:00:00Z20172025-04-18T23:36:15.737Z2019-03-26T22:49:19ZS-EPMC53320702824900210.1371/journal.pone.0171055