{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["West AV"],"funding":["Villum Fonden","Novo Nordisk Fonden"],"pagination":["43800"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5338316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of "],"journal":["Scientific reports"],"pubmed_title":["Dynamics of cancerous tissue correlates with invasiveness."],"pmcid":["PMC5338316"],"funding_grant_id":["NNF12OC1015992","00007172"],"pubmed_authors":["Tarp JM","Mathiesen J","Oddershede LB","Christensen A","West AV","Wullkopf L","Erler JT","Leijnse N"],"additional_accession":[]},"is_claimable":false,"name":"Dynamics of cancerous tissue correlates with invasiveness.","description":"Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Mar","modification":"2025-04-26T17:57:48.544Z","creation":"2019-03-27T02:37:52Z"},"accession":"S-EPMC5338316","cross_references":{"pubmed":["28262796"],"doi":["10.1038/srep43800"]}}