biostudies-literatureWest AVVillum FondenNovo Nordisk Fonden43800https://www.ebi.ac.uk/biostudies/studies/S-EPMC5338316biostudies-literatureUnknown7Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of Scientific reportsDynamics of cancerous tissue correlates with invasiveness.PMC5338316NNF12OC101599200007172Tarp JMMathiesen JOddershede LBChristensen AWest AVWullkopf LErler JTLeijnse NfalseDynamics of cancerous tissue correlates with invasiveness.Two of the classical hallmarks of cancer are uncontrolled cell division and tissue invasion, which turn the disease into a systemic, life-threatening condition. Although both processes are studied, a clear correlation between cell division and motility of cancer cells has not been described previously. Here, we experimentally characterize the dynamics of invasive and non-invasive breast cancer tissues using human and murine model systems. The intrinsic tissue velocities, as well as the divergence and vorticity around a dividing cell correlate strongly with the invasive potential of the tissue, thus showing a distinct correlation between tissue dynamics and aggressiveness. We formulate a model which treats the tissue as a visco-elastic continuum. This model provides a valid reproduction of 2017-01-01T00:00:00Z2017 Mar2025-04-26T17:57:48.544Z2019-03-27T02:37:52ZS-EPMC53383162826279610.1038/srep43800