{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Koch M"],"funding":["National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","National Institutes of Health"],"pagination":["182-187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5338868"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["<h4>Introduction</h4>Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins.<h4>Methods</h4>We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants.<h4>Results</h4>CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (<i>r</i> = 0.7). CSF apoA-I correlated similarly strong with plasma total apoA-I and all apoA-I subspecies (<i>r</i> ≥ 0.4) exc"],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pubmed_title":["Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma."],"pmcid":["PMC5338868"],"funding_grant_id":["R01 NS089638","1R01NS089638‐01A1"],"pubmed_authors":["Koch M","Furtado JD","Leypoldt F","Mukamal KJ","Falk K","Jensen MK"],"additional_accession":[]},"is_claimable":false,"name":"Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma.","description":"<h4>Introduction</h4>Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins.<h4>Methods</h4>We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants.<h4>Results</h4>CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (<i>r</i> = 0.7). CSF apoA-I correlated similarly strong with plasma total apoA-I and all apoA-I subspecies (<i>r</i> ≥ 0.4) exc","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-05-05T11:50:19.031Z","creation":"2025-06-01T12:11:28.25Z"},"accession":"S-EPMC5338868","cross_references":{"pubmed":["28289700"],"doi":["10.1016/j.dadm.2017.01.007"]}}