biostudies-literatureKoch MNational Institute of Neurological Disorders and StrokeNINDS NIH HHSNational Institutes of Health182-187https://www.ebi.ac.uk/biostudies/studies/S-EPMC5338868biostudies-literatureUnknown6<h4>Introduction</h4>Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins.<h4>Methods</h4>We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants.<h4>Results</h4>CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (<i>r</i> = 0.7). CSF apoA-I correlated similarly strong with plasma total apoA-I and all apoA-I subspecies (<i>r</i> ≥ 0.4) excAlzheimer's & dementia (Amsterdam, Netherlands)Apolipoproteins and their subspecies in human cerebrospinal fluid and plasma.PMC5338868R01 NS0896381R01NS089638‐01A1Koch MFurtado JDLeypoldt FMukamal KJFalk KJensen MKfalseApolipoproteins and their subspecies in human cerebrospinal fluid and plasma.<h4>Introduction</h4>Subspecies of apolipoproteins can be defined by fractionating apolipoproteins based on the presence and absence of coexisting apolipoproteins.<h4>Methods</h4>We determined age- and sex-adjusted correlations of enzyme-linked immunosorbent assay-measured plasma and cerebrospinal fluid (CSF) apolipoproteins (apoA-I, apoC-III, apoE, and apoJ) or apolipoprotein subspecies (apoA-I with and without apoC-III, ApoE, or apoJ; apoE with and without apoC-III or apoJ) in 22 dementia-free participants.<h4>Results</h4>CSF apoE did not correlate with plasma apolipoproteins or their subspecies. CSF apoJ correlated most strongly with plasma apoA-I without apoJ (<i>r</i> = 0.7). CSF apoA-I correlated similarly strong with plasma total apoA-I and all apoA-I subspecies (<i>r</i> ≥ 0.4) exc2017-01-01T00:00:00Z20172026-05-05T11:50:19.031Z2025-06-01T12:11:28.25ZS-EPMC53388682828970010.1016/j.dadm.2017.01.007