biostudies-literatureHampras SSCancer Research UKNCATS NIH HHSNCRR NIH HHSNIEHS NIH HHSThe Francis Crick InstituteMedical Research CouncilNCI NIH HHSNLM NIH HHSNIGMS NIH HHS69097-69110https://www.ebi.ac.uk/biostudies/studies/S-EPMC5340115biostudies-literatureUnknown7(43)<h4>Background</h4>Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.<h4>Methods</h4>In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.<h4>Results</h4>The most significant global associations for all genes in the pathway were seen in endomeOncotargetAssessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.PMC5340115K01 LM012100R01 CA080742P50 CA159981P01 CA087969U19 CA148537R03 CA113148R01 CA054419R01 CA149429R01 CA128978P20 GM103418P30 CA014089P50 CA105009N01 PC067010P01 CA017054K07 CA09566616561R01 CA076016R21 GM086689K22 CA138563R01 CA126841R01 CA067262U01 CA058860R01 CA064277R01 CA106414R01 CA087696P30 CA016056P50 CA136393N01 CN025403P30 CA015083R01 CA087538K07 CA092044R01 CA136924UM1 CA186107UM1 CA18291015960P30 CA008748K07 CA080668R01 CA049449T32 ES013678UL1 TR001863P30 CA07178910119R01 CA122443K07 CA143047R01 CA114343R01 CA058598M01 RR000056R01 CA112523R01 CA074850R01 CA050385G0501974R03 CA115195R01 CA188900N01 PC035137P30 CA072720R01 CA168758R01 CA063682R37 CA070867P30 CA168524UM1 CA176726U01 CA069417R01 CA058860U19 CA14811210124R01 CA083918Heitz FDork TSouthey MCEng KHCannioto RHong CCWallace PKSieh WPreus LLubinski JNedergaard LDicks ELiang DWalsh CPerkins BClay ABjorge LGronwald JOdunsi KGentry-Maharaj AHampras SSLundvall LMcNeish ISalvesen HBShvetsov YBBogdanova NEaston DEkici ABKnutson KLSchernhammer EKelemen LEZheng WHillemanns PLester JTworoger SSModugno FPearce CLHein APermuth-Wey JRzepecka IKHosono SKarlan BYRudolph AGayther SALevine DAVierkant RABisogna MHasmad HNHarrington PBean YKlapdor RDansonka-Mieszkowska APhelan CMCarty KSchildkraut JMZiogas ALambrechts SAntonenkova NPelttari LMWang-Gohrke SGoodman MTCampbell IGNarod SAWilkens LRHogdall CNess RBLambrechts DHogdall EWentzensen NWicklund KGBaker HMoes-Sosnowska JRisch HAWhittemore ASWu AHCybulski Cdu Bois ARossing MASiddiqui NPaul JDavis WKolomeyevskaya NLee AWWeber RPMatsuo KTangen ILPike MCHarter PTimorek ATsai YYWoo YLPharoah PPHildebrandt MAChenevix-Trench GSellers TAKruszka BWu XKellar MPlisiecka-Halasa JYang HKiemeney LAChang-Claude JMassuger LFRunnebaum IBKupryjanczyk JNickels SFasching PASchwaab ITeo SHLu KEccles DNevanlinna HThompson PJLeminen ABrooks-Wilson AKjaer SKBerchuck ALe NDPoole EMAnton-Culver HBrinton LATerry KLCook LSBandera EVDoherty JAOlson SHLiu SPejovic TDespierre EJensen AKrakstad CMenon USucheston-Campbell LEGao YTBeckmann MWGiles GGRamus SJCunningham JMJoseph JMMcLaughlin JROrlow ISingh PKKelley JLCramer DWDurst MMcGuire VShu XOAben KKMoysich KBVergote IEdwards RPDennis JSong Hvan Altena AMSchoof NGlasspool RJi BTIversen ESRothstein JHSchmitt KButzow RLele SFriel GJakubowska AFridley BLLissowska JNesline MBruinsma FTyrer JGoode ELfalseAssessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.<h4>Background</h4>Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.<h4>Methods</h4>In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.<h4>Results</h4>The most significant global associations for all genes in the pathway were seen in endome2016-01-01T00:00:00Z2016 Oct2026-05-30T01:47:51.649Z2019-03-27T02:38:00ZS-EPMC53401152753324510.18632/oncotarget.10215