{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(46)"],"submitter":["Liu S"],"pubmed_abstract":["Cervical cancer is one of the most common malignant tumor in women. The mechanisms of cervical cancer are intricate and have not been fully understood. Therefore, we employed iTRAQ to obtain novel proteins profile which participates in the tumor oncogenesis of cervical cancer. 3300 proteins were identified aberrantly expressed in cervical cancer, and western bolt was performed to validate the results of iTRAQ. Then, we selected LYN for further study. Immunohistochemistry identified that LYN expression was significantly increased in cervical cancer tissues than that in cancer adjacent normal cervical tissues and normal cervical tissues. The increased LYN expression was significantly correlated with cancer differentiation and FIGO stage. Silencing LYN inhibited cell proliferation, migration "],"journal":["Oncotarget"],"pagination":["75468-75481"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5342753"],"repository":["biostudies-literature"],"pubmed_title":["Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study."],"pmcid":["PMC5342753"],"pubmed_authors":["Yang Y","Ouyang X","Dong X","Hu J","Hao X","Yu T","Liu S","Hu L"],"additional_accession":[]},"is_claimable":false,"name":"Tyrosine kinase LYN is an oncotarget in human cervical cancer: A quantitative proteomic based study.","description":"Cervical cancer is one of the most common malignant tumor in women. The mechanisms of cervical cancer are intricate and have not been fully understood. Therefore, we employed iTRAQ to obtain novel proteins profile which participates in the tumor oncogenesis of cervical cancer. 3300 proteins were identified aberrantly expressed in cervical cancer, and western bolt was performed to validate the results of iTRAQ. Then, we selected LYN for further study. Immunohistochemistry identified that LYN expression was significantly increased in cervical cancer tissues than that in cancer adjacent normal cervical tissues and normal cervical tissues. The increased LYN expression was significantly correlated with cancer differentiation and FIGO stage. Silencing LYN inhibited cell proliferation, migration ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Nov","modification":"2025-04-19T19:45:31.349Z","creation":"2019-03-27T02:38:13Z"},"accession":"S-EPMC5342753","cross_references":{"pubmed":["27690342"],"doi":["10.18632/oncotarget.12258"]}}